BOTOX Cosmetic – The First FDA-approved prescription medicine injected into muscles and used to temporarily improve the look of both moderate to severe crows feet lines and frown lines between the eyebrows. Softens dynamic wrinkles by relaxing overactive facial muscles. Effective between the brows, at edges of the eyes, on the nose, and forehead. Smooths worry lines, frown lines, crows feet and bunny lines. Quick, 10-minute treatment lasts up to 3 months. Minimal Discomfort.